Aspirin SAC

[ch]

Does any one know if aspirin is soluble in HCl, eucalyptus oil and Water?

[zhe0001]

Does any one know if aspirin is soluble in HCl, eucalyptus oil and Water?

Hey,
This is based on my knowledge of polarity and a little research.
As you know 'Like dissolves Like', Polar dissolves with Polar and Non Polar dissolves with Non Polar.
Aspirin is polar
Water is polar, aspirin will therefore dissolve
HCL is polar, aspirin will therefore dissolve
Eucalyptus oil is non-polar, aspirin will therefore not dissolve

I hope this answers your question

[ch]

What about in nacl?

[zhe0001]

What about in nacl?

Not too sure. Doesn't it depend on what state NaCl is in?
But I know for sure that NaCl is polar due to electronegativy difference.
May I ask why it asks these questions?

[ch]

It is determining the solubility for aspirin in various solvents in preparation of SAC questions regarding the purification of aspirin.

[ch]

How does the solubility of aspirin in different solvents help us determine the different pathways aspirin takes when going through the gastrointestinal tract?

[zhe0001]

How does the solubility of aspirin in different solvents help us determine the different pathways aspirin takes when going through the gastrointestinal tract?

I'm not too sure about the gastrointestinal tract, but I know for sure that aspirin will pass through the digestive system where HCl is the main acid where it breakdowns ie. food particles. The fact that aspirin can dissolve in HCl suggests that the body will able to absorb aspirin?
Edit: Another thing - the fact that aspirin is soluble in water also suggests that it is able to enter the bloodstream.

[ch]

Aspirin also dissolves in nahc03 though does that mean it gets dissolved in the intestines as well. That seems a little strange if its already dissolved in the stomach.

[zhe0001]

Aspirin also dissolves in nahc03 though does that mean it gets dissolved in the intestines as well. That seems a little strange if its already dissolved in the stomach.

Good point. The stomach containing HCl is where the breakdown occurs. When it passes through the intestines it is the villi that absorb the aspirin.
I feel as if this is more of a biology question than chemistry hahha.

Edit: You're right. Aspirin is more soluble in basic (nahc03) solutions, so it readily dissolves in the duodenum - intestine, first part