Can someone please explain to me about the Rh +ve and Rh -ve relationship between a mother and her baby and what is the function of a doctor injecting Rh antibodies into the mother?
So this circumstance only occurs when :
- Rh -ve mother
- Rh +ve child
Remember Rh antigens are proteins on the surface of RBC.
So once the mother gives birth the child's blood may pass through the placenta and into her body. Because she is Rh negative her immune cells will detect it as foreign, leading to the production of antibodies and what is most important here - memory B cells.
The real problem , however, occurs at the second child (given that he/she too is Rh +ve)
During pregnancy some cells will pass through to the mother. Antibodies are produced rapidly and greatly. They will attack the childs RBC leading to damage and causing haemolytic disease ,where child is yellowy because RBC lyse and haemoglobin is released.
Now at each subsequent pregnancy response will be stronger and greater, due to the presence of memory B cells.
How can we prevent this? At the first child birth the mother is injected with antibodies for the Rh factor (this is passive artificial immunity) so that she doesn't produce her own , and no memory cells are produced. This is repeated at each child birth .