I think I understand exactly how you feel...
I would like to share some of my story , hope that will help you:
I am considered to be popular in first year, because I participated in a lot of club + social + volunteering activities. I had at least made over 100 friends at the time. By friend, I mean a person know you, and you know them. You do talk and hang out with each other, maybe not regularly, but to some extend.
It was very time consuming to keep up the social life, especially when you are a person who cares about how your friends feel.
I never worried about been alone in uni at the time, because I know I can almost call up anyone to accompany me at any given time.
I could stay overnight at many of my female friends places after uni, so that tells you how my relationship are with them.
However, everything changed when few incidents happened to me in a row at start of my second year... I can't tell you exactly what have happened, but I can tell you it was beyond bad...
I saw how bad humanity can be, so bad that made me hate this world, sincerely wish this world could end the next day.
I saw how this ugly society destroyed young lives, destroyed hopes...
I was swallowed by this grief and hatred...
My results started to drop rapidly, and I started to isolate myself from others...
One night I was sitting in a hospital after an incident , looking through my list of contacts, 400+ of them... yet there is no one I can call to share my feelings.
I realized, there is no point telling what have happened to anyone. No one will understand, nor cares to begin with.
It is until this point, I started to realize, I had so much quantity, but what about the quality?
The answer started to become obvious after few things that I tried...
I tried to talk to my most reliable friends about what have happened, I realized it's hard for people to understand without being through it themselves... Soon after, I felt no point telling them anymore...
I tried to ask for some help academically from those people I used to help out a lot, it turns out they often have more important things to busy with. (e.g: play PS3.)
I tried to regain social life by going out with people that I used to invite when I am hosting parties, turns out I have became a foot-stone that they use to approach new female.
Finally , I decided to shut myself away from everyone else.
no message reply, no pick up phone call.
My friends became frustrated.
Despite what have happened, I still have to attend uni and do group report all by myself. Because my group member never bother to do anything, and I am not allowed to change group.
Also because student center decided that I had not enough evidence to apply for a late withdraw nor special consideration.
So it was totally fucked up.
I ended up with few fails and a warning of possible expel if this happens again.
I think my situation is as bad as anyone could ever get when they are in uni.
However, I decided to take a gap and few months later, after endless day and night grieving...
I started to ask myself, what do I want to do with my life, and what are the things that still needs to be done when I am alive.
I realized I still have my parent to take care of, I still have to look after a kid that I found, she was abundant by their parents. I am their hope, and I can't let them down.
While still having the hatred, and hopeless feelings in my heart. I started to push myself.
I started by setting a goal for income, so I planned everything possible in earning money. Started executing them one by one.
With my hard earned money, and tons of studies in my own time on other areas, I brought a car and a big house.
a year later, I got back uni and started taking 2 subjects per semester.
Realizing that all my friends have graduated, and I am totally alone.
Sitting in the lecturers without knowing anyone surely feel awkward, plus knowing you are older than everyone else, that's even worse.
My grades wasn't stable, because I don't have motivation of going to lecturers, plus having no one to help me when I encounter difficulties.
However, I recall how I made friends in first year.
I then started to open up with people like how I once was in first year.
Start asking people questions, try to help people out during tutorials, try to chat with them, discuss with them.
I then made few friends, started forming a small study group.
It is this small study group that helped me in my assignments, it is also this small study group that motivated me again. (Because I don't like to be the dead weight that only ask for help.)
Meanwhile, I was lucky enough to be able to meet few CEOs of some engineering company. I was kindly given days of work experience in their company. The colleague were nice and supportive, told me a lot of things that I will never learn in uni. This has given me an insight of what I want to do in the future.
Lastly, I will quote two sentence from my close friends:
"Friends isn't about quantity, it's about quality. But in a life time, you will only have one or few of these quantity friends. You just simply wouldn't have enough time and effort to maintain more."
"We all say time can fade everything, but I believe a good friend means regardless how long your haven't been talking to each other, your friendship should still last like it was before."
I will also quote few statements my other friends used say about me:
"You are a retard, and you don't have a brain." says the PHD friend who spend entire free time playing games.
"You are a loser, and you are afraid of fighting back." says the accountant friend who decided to take a gang of people into my house and wanting to pick a fight with me.
"You are like a dark cloud, bringing negative feelings to everyone." says the person I cared the most at the time.
In the end, whether you are loser or not, it's about what you think.
It is your decision to whether or not to go out and make friends.
It is your decision to whether or not to push yourself in studies.
It is your decision to whether or not to pursuit your goal.
It is your decision to live however you like with your life.
You will never know what is going to happen next.
Life can be shit, but when shit happens, you should be prepared to clean it up and say: "BRING IT, FUCKERS!!"