Thanks so much! Great explanation.
Btw what are the constituents of hormones? I know they're chemical messengers; I feel as if that's a vague understanding though.
Hormones are chemical signalling molecules produced by one type of cell, that diffuse through extracellular fluid to act on the cell they were synthesised by (autocrine signalling), neighbouring target cells in the intermediate vicinity (paracrine signalling) or travel through the bloodstream and act on target cells situated far away (endocrine signalling). Hormones act in minute quantities and produce profound responses by specific target cells. Target cells are specific cells that have specific receptors for specific signalling molecules.
Hormones fall into one of three categories:
(a) Lipid-soluble hormones; these are hormones that are hydrophobic in nature, and so are able to readily diffuse throught the phospholipid bi-layer of target cell membranes, and bind to specific hormone receptors within the cytosol of these target cells, activating several molecules in a transduction pathway, and eventually leading to a specific cellular response.
(B) Water-soluble hormones; protein hormones (made up of more than 200 amino acids) and peptide hormones (made up of less than 200 amino acids) are water-soluble. As a result, they are unable to readily cross the phospholipid bi-layer of target cell membranes. As a result, these hormones have protein receptors located on the outside of these cells. Once the specific water-soluble hormone binds to this protein receptor, a secondary messenger molecule (like a G protein) is activated, and carries the message through the cell. During this transduction phase, many molecules in the pathway are activated, and the last molecule in the pathway brings about the specific cellular response. This process by which the cell receives a signal, and the cascade of events following this leading up to the response by the cell, is called signal transduction.
These cellular responses can include:
(a) The synthesis of a protein (through gene expression)
(b) Increased permeability of the cell membrane to a substance (e.g. insulin increases the permeability of target cell membranes to glucose, for cells to increase glucose uptake and thereby reduce blood glucose levels).