I am not even close to knowledgeable on nuclear power, but one issue that comes to my mind is the storage of nuclear waste. These things can be dangerous for a very very long time and storing it is a big issue. Even if we store it deep under ground with hundreds of warning signs and what not, what is stopping a person 10000 years from now who has no sense of our language or diagrams to dig up this waste and potentially harm many. https://youtu.be/uU3kLBo_ruo. I found this video quite interesting.
With molten sand reactors, waste from modern reactors like those in France and America is used as part of the Fuel cycle, and handily destroyed.
i.e: No more hella dangerous Plutonium 239...
well, very little, anyway....If we use these molten sand reactors fueled with thorium 232, there is a much lower chance of generating Transuranic waste, as the thorium fuel cycle ends with Uranium 233, which has a neutron capture ratio of 1:12, compared with U235's 1:6 or Pu239's 1:3.
The more neutrons that are captured, the greater the number of reactions, and the greater overall efficiency of the reactor.
The video is extremely interesting and poses a good question. The feasibility of none of the five UN languages being spoken in 10000 years does pose an issue, but I think that sufficient signage of skulls and similar should suffice. I personally don't see any issue with the nuclear waste being here if another species happened to colonise this planet once the humans are all gone. If they are keen to come here, they can take the good with the bad...