Hey:)
Are the marker molecules on the surface of transplanted organs which cause an immune response referred to as antigens or is it that they have a different MCHI molecule?
Also, one of the focus areas for the search for better health topic refer to a scientist called Macfarlane Burnet but I dont seem to have any notes on him. Is there anything specific we need to know about him?
Marker molecules are actually protein flags on all of the tissues within the body. The reason why an immune response occurs is due to the fact that invading foreign bodies (not necessarily pathogens) have different sets of these flags (different types, too many, too little or none at all) and that triggers an immune response as the body detects the antigen as 'Non-Self'
When an organ is transplanted that isn't similar to the patient's tissue type or when a person who has had a transplant stops taking immunosuppressants then the immune response attacks the organ.
The protein flags themselves are not antigens but the human immune system recognises them as non-self and will treat the organ as though it is an antigen.
Hope this helps