Immunology tolerance wasn't discovered by Burnet, it was him that discovered the method by which humans gain their acquired immunity, I don't know the logistics of this but he did research into the 3 lines of defence.
He wasn't the first to observe tolerance, no doubt; but he was certainly the one to describe it, and as I said, Medawar provided the evidence to support Burnet's theorising.
Burnet's research was very broad. He started off as a microbiologist, with a particular interest in viruses. In fact, he is credited with the discovery of the causative agent of so-called Q fever, which is named after him (
Coxiella burnetii). If I remember correctly, he was initially very interested in influenza, but decided to make the switch to immunology. Obviously he won the Nobel for describing immunological tolerance; however, arguably his biggest contribution to the field was the discovery of clonal selection/expansion (which I presume you guys probably learn about?). If not, his theory described the way by which cells of the third line of defence—T-cells and B-cells—respond specifically to pathogens.
PS: given this is an HSC biology thread it would remiss of me to not remind you that Macfarlane Burnet was born, educated and worked all of his life in Victoria :p