non competitive reversible inhibition

[shininay]

Must you always refer to the inhibitor changing the ENZYME shape but not the active site? All my texts only refer to the changing of the enzyme shape and I was curious to whether I'd be wrong if I wrote otherwise.

ALSO, if a tertiary protein structure made of only one polypeptide?

MANY MANY THANKS

[alondouek]

1. Non-competitive inhibition involves the inhibitor binding to the enzyme at a location other than the active site. This changes the shape of the enzyme, hence the specific shape of the active site is also distorted.

2. Yep! A tertiary protein consists of only one highly folded polypeptide sequence. Quaternary structure is when you have two or more tertiary proteins bonded together.