I really cant complain cos I lucked out on some questions not being asked 
but yeah it was hard no doubt and super draining. Hope pharm went okay on tuesday : )
As for the chromosomal translocation thing, he did say 2 specific examples but only 2. But I think you could be creative and say a promoter can get near myc or something as scribbles said. I said bcr/abl and Bcl2 overexpression.
John's section was weird, like I chose Q1 and Q5 and I had to re-iterate the exact TNF pathway twice.
What was the answer to 'how do we know it's important to turn off TNF promptly'? I said rats and people get psoriasis..... wait fukk I JUST remembered there are drugs that block TNF and people get cured of psoriasis. fuck!
Oh well Im just glad I dont have to learn about substitution matrices and maximum parsimony tree building ever again.
In retrospect the subject was one of the most interesting I've ever taken although it was also the hardest no doubt. The cancer section is one of my favourite parts of any subject I've done. Johns stuff was easily the worst. Crispy creme Cas was alright too.
A bit rough to ask a question when he's given only the two, but oh well. I hope he doesn't punish people for using examples that he didn't discuss. The one I put about IgH and myc was completely right. In 100% of Burkitt's lymphoma there's a translocation that sees myc put under the influence of the IgH promoter. Indeed, that's actually the same way you get overexpression of Bcl2 in most cases. Chronic lymphocytic leukaemia and follicular lymphoma tend to have translocations that do that. <---- may be revising for my exam tomorrow a little with that haha!
John's section was a bit odd, though nowhere near as weird as I'd expected. He didn't really drive them home that much, but A20 -/-, TNF overexpression and the anti-TNF monoclonal antibodies for psoriasis and arthritis were the three pieces of evidence I think he discussed. I think that one was probably enough though.
Interesting way of looking at the subject actually. My experience was completely the opposite. I found the cancer stuff to be a bit of a drag to be honest. That said, at the time I was doing cancer in my other two subjects as well. Had one day when I had three lectures in a row that discussed the hallmarks of cancer -_-
John's stuff, on the other hand, I thought was pretty interesting, if nearly incomprehensible. Stuart's stuff was pretty cool too actually, though it did become a little tedious after the first few lectures.
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