Question.... HELP!

[monokekie]

In cardiac myocytes, the force of contraction has a positive relationship with intracellular Ca2+ stores. Ca2+ efflux from these cells is largely mediated by a Na+/Ca2+ exchanger that does NOT directly ultilise ATP hydtolysis, but instead is powered by the electrochemical gradient of Na+ ions acroos the cellular membrane. Form and justify a hypothese on the effect of digoxin, an inhibitor of NA+/K+ ATPase, on the intracellular Ca+ levels, and contractility of these cells. (5 marks)

Thanks soo much in advance~~~

[monokekie]

Would the hypothesis be:

The presence of Digoxin would increase the intracellular Ca+ levels, and the contractility of the cells will increase as it has a positive relationship with the incracellular Ca2+ stores.

Because digoxin inhibits the Na+/K+ ATPase which pumps sodium ions into the cell, and there would be less Sodium ion efflux which means less Ca2+ can be transported outside of the cell. So the concentration of Ca2+ ion increases intracellularly.

Does this sound bout right?

[monokekie]

dwdw~ a friend helped solve it ~~~

Thanks anyway~~ for those who have viewed it ^_^

still appreciated xD