There's 2 ways depending on whatever floats your boat.
1. The magnitude of |PQ| can be used. Find the minimum under the square root and thus you found the minimum t at which this occurs. [This is utilizing the result from b) ii)]
2. You can also dot the velocity vectors of OP and PQ and find when it equals 0, you must dot the velocity vectors and not the displacement because they give the direction of motion. [Since two particles are closest when they are perpendicular to each other, ie a straight line, notice this would only work if the path they travel in is a straight line.] But for this question you don't know the velocity vector for time t thus you should go with option 1.