Does cell mediated immunity effectively lead to humoral immunity?

[forchina]

Does cell mediated immunity effectively lead to humoral immunity?

[Snorlax]

T-cells are involved with B-cells (work together in clonal selection)
If that's what your after ?

[forchina]

I mean when B cells presents antigen it engulfed on MHC marker 2, and then specific T helper cell's receptor for antigen binds with it and the T cell  is activated, secreting cytokines which (Humoral Immunity now -) activate B cells to differentiate to many plasma cells and also some B memory cells. The plasma cells will then release their antibodies.

[simpak]

Yes, but remember that cell mediated immunity is responsible for other things that don't involve antibodies too - for instance killing by Killer cells.  So yes, but the function of cell-mediated immunity doesn't lead exclusively to the production of humoral immunity.

[Yacoubb]

Someone correct me if I'm wrong, but this is my understanding of it.

When a macrophage detects a foreign, non-self antigen, it binds to it, engulfs it and eventually destroys it by digestive enzymes which break down the antigen. Antigen fragments are presented to Helper T Cells at the MHC 2 marker; when the Helper T Cell is actually activated, it begins to do two things. Firstly, it leads to the production of many B-lymphocytes in order to produce antibodies specifically designed to bind to the antigens of the detected non-self antigen. This is part of the humoral response; that is, any of the antigens floating around in the extracellular fluid can be detected and eventually destroyed the humoral immune response. At the same time, the Helper T Cells activate cytotoxic t-cells. These cytotoxic t-cells are produce to kill cells that are infected by specific non-self antigens; hence, this mode of immune response is called a cell-mediated immune response.

I'd say that the production of antibodies by the B-lymphocytes works in conjunction with more macrophages being produced as well, as part of the adaptive, "humoral" immune response, in addition to cytotoxic T-cells that release enzymes to break down cells that are infected by specific non-self antigens.

[simpak]

Just a note on your post above: remember than the helper T cell can't do anything to help the response of a killer T cell if the killer T cell has not been engaged by antigen on an MHC-I in a separate event as well, so you should include that in your response.
Secondly, make sure you don't say that the helper T cell 'leads to the production of many B cells' - this is technically correct but slightly misleading because you haven't told me that that specific B cell was present prior to the helper T cell activation.  So a better way to say it would be 'the helper T cell aids activation of a B cell specific to the same antigen, which then proliferates to create many clones that differentiate into effector cells'.  Just if I am being picky :3

[psyxwar]

Just a note on your post above: remember than the helper T cell can't do anything to help the response of a killer T cell if the killer T cell has not been engaged by antigen on an MHC-I in a separate event as well, so you should include that in your response.
Secondly, make sure you don't say that the helper T cell 'leads to the production of many B cells' - this is technically correct but slightly misleading because you haven't told me that that specific B cell was present prior to the helper T cell activation.  So a better way to say it would be 'the helper T cell aids activation of a B cell specific to the same antigen, which then proliferates to create many clones that differentiate into effector cells'.  Just if I am being picky :3

damn how is your expression so good Z_Z

Would we need to know about how NK and cytotoxic T-cells can use granzyme to induce apoptosis in viral infected cells?

[Yacoubb]

Just a note on your post above: remember than the helper T cell can't do anything to help the response of a killer T cell if the killer T cell has not been engaged by antigen on an MHC-I in a separate event as well, so you should include that in your response.
Secondly, make sure you don't say that the helper T cell 'leads to the production of many B cells' - this is technically correct but slightly misleading because you haven't told me that that specific B cell was present prior to the helper T cell activation.  So a better way to say it would be 'the helper T cell aids activation of a B cell specific to the same antigen, which then proliferates to create many clones that differentiate into effector cells'.  Just if I am being picky :3

Thanks for that!

[simpak]

I can't remember if I had to know about granzyme /and/ perforin in Year 12 Biol, but if you know about it I don't think it would hurt to have a vague or general idea.