A new mother presents to her paediatrician worried that her son is smaller than other people his age. After some investigation, the doctor determines that the mother is correct, and diagnoses the child as having an issue with his growth. The doctor suspects that the child has an issue with growth hormone and investigates. He discovers that the anterior pituitary is normal and the gene for growth hormone is also normal.
Looking at the pathway provided below, give three different reasons the baby isn't growing properly.
(Image removed from quote.)
1)The boy has high stress and cortisol levels resulting In the hypothalamus not triggering the release of GH by anterior pituitary gland
2)The boy is malnutrition(ed?) and does not eat enough resulting in the hypothalamus not triggering the release of GH by anterior pituitary gland
3)Receptors on some or most bone and muscle cells responsible for attaching to growth hormone and initiating the 'growth' response are not properly shaped complementory to the growth hormone, thus causing the inability of the 'growth' response
Full guessed but hopefully i hit at least 1 of the marks.
Also, For 2013 question 5)b) A teenager with a family history of an autoimmune disease underwent a genetic screen for the disease. After
receiving a positive result for the genetic screen, she had an additional autoantibody test. The result of this
autoantibody test was negative.
Explain why the autoantibody test could be negative even though the genetic screen was positive
The answer seems really vague for me. My answer was something got to do with the antigens on the tissue cells which is affected by the particular autoimmune disease being misshaped and likely to be read as non-self, however the specific lymphocytes that are responsible for this have not yet come into contact with these antigens.
So im probably not correct but even so, if someone is screened as having an autoimmune disease, what does that mean? Do they have misshapen antigens on self-cells or is that not even how it works