why does the humoral response involve the MHC 2 marker, while the cell mediated response involves the MHC 1 marker?
MHCI is recognised by CD8 cells, which then destroy the cell they bind. That makes it directly cell mediated.
MHCII is recognised by CD4 cells, which are responsible for activating B cells, which produce antibodies. That makes it "humoral" because the antibodies are soluble in the serum etc.
Does negative feedback work by simply causing a change in the variable being detected, or does it act directly on the gland (i'm sure its the first one but some sources imply otherwise) i.e. when drawing a negative feedback diagram, should i draw the feedback arrow to the stimulus, or the gland producing the hormone?
How does it cause a change in the variable/stimulus without affecting the gland? If there's too much sugar in the blood, you can't just magically reduce it, you have to stimulate the pancreas to produce insulin to insert GLUT4 into cell membranes to transport sugar out of the blood.
5) Do leukocytes phagocytose eukaroyttc pathogens? Neap says they do but Campbells says otherwise
Depends what you mean by leucocytes and phagocytose. Eukaroytic pathogens generally aren't phagocytosed because they're too big...but phagocytes are involved in their clearance, as are other cells. Degranulation and oxidative burst to produce various toxic molecules are important clearance mechanisms.
q4 is biochem and i can't remember it clearly enough right now. google and wikipedia might help you out