SAC 4!

[Charmz]

I'm going to be doing Polio for mine. The SAC is really stupid, we have to do a powerpoint or poster. And its in two weeks which is soooo stupid because we haven't even finished the unit 3 course! And 75% of my class have not ever looked at a single exam paper yet and the most someone has done (except me) is 3 VCAA exams!

[HERculina]

ok i have decided to go with Tuberculosis

Tuberculosis is a favourite of mine and it's also a fairly clear immune response.

Can you please explain step-wise how it effects the immune system?
or link me to a site/animation that explains it good? (most of the webistes ive clicked on don't really relate to immunity)
and how could i link Tuberculosis with the concept of recognising 'non-self' and 'self'

[Russ]

The immune response is basically just CMI. Macrophages attacking the bacterium and when they fail to eliminate it from the lungs, they wall it off by forming a granuloma.

from http://ajrccm.atsjournals.org/cgi/content/full/157/3/679

The initial defense against infection with M. tuberculosis, once it reaches the lower respiratory tract, is the alveolar macrophage...This cell is capable of inhibiting growth of the bacillus through phagocytosis, and, as will be discussed later, of participating in a broader context of cellular immunity through the process of antigen presentation and recruitment of T-lymphocytes.

Other immune cells offer substantial help to the macrophage in controlling growth of mycobacteria. T-lymphocytes can be recruited to the macrophage and further stimulate it to inhibit growth of or kill mycobacteria. Cytotoxic T-lymphocytes can ingest macrophages that have engulfed mycobacteria. They can also secrete small proteins such as TIA-1, a cytoplasmic molecule that has been shown to be associated with apoptosis

Once a macrophage has been activated to inhibit growth of mycobacteria, a variety of cellular mechanisms are available to accomplish this effector function. It has long been known that reactive oxygen species such as superoxide anion and hydrogen peroxide are important components of host defense against a variety of microorganisms...Protection against ROI Reactive Oxygen Intermediates by mycobacteria may be achieved by a variety of bacterial components or products, including the detoxifying effects of LAM...sulfatides ...and possibly a substance known as PGL-1. The most abundant protein secreted by M. tuberculosis in short-term culture is the 23-kD antigen superoxide dismutase; catalase is secreted as well

Upon reflection the immune response is clear/well delineated but it doesn't really span every concept
Maybe a virus would be better if you need to outline self/nonself - with TB it's just the phagocyte PAMP/Complement etc. receptors binding a non self bacterium

[Russ]

How much detail do you need to go into? Because the GBS pathology isn't VCE level :S

[WhoTookMyUsername]

Well it's an MHS SAC, 1000 word limit, so I assume not too much about specifics, more about general immune action

[Truck]

We had the same SAC, i did chickenpox. It was a rather easy choice.

HEY there, I'm doing Chickenpox, any tips =P. lol.

[HERculina]

The immune response is basically just CMI. Macrophages attacking the bacterium and when they fail to eliminate it from the lungs, they wall it off by forming a granuloma.

from http://ajrccm.atsjournals.org/cgi/content/full/157/3/679

The initial defense against infection with M. tuberculosis, once it reaches the lower respiratory tract, is the alveolar macrophage...This cell is capable of inhibiting growth of the bacillus through phagocytosis, and, as will be discussed later, of participating in a broader context of cellular immunity through the process of antigen presentation and recruitment of T-lymphocytes.

Other immune cells offer substantial help to the macrophage in controlling growth of mycobacteria. T-lymphocytes can be recruited to the macrophage and further stimulate it to inhibit growth of or kill mycobacteria. Cytotoxic T-lymphocytes can ingest macrophages that have engulfed mycobacteria. They can also secrete small proteins such as TIA-1, a cytoplasmic molecule that has been shown to be associated with apoptosis

Once a macrophage has been activated to inhibit growth of mycobacteria, a variety of cellular mechanisms are available to accomplish this effector function. It has long been known that reactive oxygen species such as superoxide anion and hydrogen peroxide are important components of host defense against a variety of microorganisms...Protection against ROI Reactive Oxygen Intermediates by mycobacteria may be achieved by a variety of bacterial components or products, including the detoxifying effects of LAM...sulfatides ...and possibly a substance known as PGL-1. The most abundant protein secreted by M. tuberculosis in short-term culture is the 23-kD antigen superoxide dismutase; catalase is secreted as well

Upon reflection the immune response is clear/well delineated but it doesn't really span every concept
Maybe a virus would be better if you need to outline self/nonself - with TB it's just the phagocyte PAMP/Complement etc. receptors binding a non self bacterium

woweee thanks russ!
that website was quite handy
im going to just stick with TB and mention slightly about self vs non-self in a different section cause too many people in my biol class are doing virus-related diseases already 
the bulk of the sac is more on how the immune system reacts so i think ill be fine

[dou0014]

I got 96%