If you're talking about things like PEOPLE and that you can't have half of, you always need to round up. For example, if you do all the calculations and find that "for a 20% chance that someone has brown eyes in the class, there must be 14.2 girls in the class", then you need to say 15. In this case, 14 girls wouldn't be enough, you can't have 14.2 girls, and 15 is just right...this doesn't just happen in probability either, but also in logs and exponentials (no examples are coming to mind, but half life questions usually seem to have this 'dilemma')
I'm not sure - someone back me up on this - but I think that if they say to round to the "nearest whole number", you have to do just that. So for the 14.2 girls example, you'd say 14. I think most questions we get will be pretty clear though.
Hope that helps