Would another one be that natural selection is unpredictable whereas artificial isnt?
I don't think this is necessarily a good one.
Say you keep applying a single antibiotic (Tuberculosis treatment uses multiple drugs [~4] for a reason), what do you think is likely to happen?
Do you think its more likely the bacteria evolve to glow green or evolve resistance?
It's not necessarily unpredictable. So, i don't think this is a good way to differentiate them.
Or that natural selection chooses the phenotype that makes population more genetically fit whereas artificial selection may not produce offspring that make the population more genetically fit and more suited to environment but is what ever benefits humans?
This is a
great one! Think about little dogs, we've bred using selective breeding. Little ones like beagles or pomeranians.


The ancestor of our dogs looked a little more like this:

Tell me which one is more fit hey

?