Principles of Neuroscience

[Pup]

what did you guys put for in for that question that asks you what would happen if you were to selectively activate the D2 receptor drug?

[ChickenCh0wM1en]

what did you guys put for in for that question that asks you what would happen if you were to selectively activate the D2 receptor drug?

No movement I think (similar to PD).

[LeviLamp]

I said more movement because Peter said in the lecture that dopamine is "ALWAYS pro-movement", like he emphasised that point when referring to action on D2 receptors in the indirect pathway. But apparently it just deselects unnecessary movements. I feel like he should take that one off the quiz @_@

[MelonBar]

I remember him saying that as well, but if you follow the pathway you get inhibition right?

[ferrsal]

Google says D2 agonists are used for treatment of Parkinson's disease so I assume they would be pro movement which then doesn't make sense if it's inhibitory in the pathway

*sigh*

[ChickenCh0wM1en]

Google says D2 agonists are used for treatment of Parkinson's disease so I assume they would be pro movement which then doesn't make sense if it's inhibitory in the pathway

*sigh*

Wow... not confusing at all LOL

I thought D2 was inhibitory. The only reason I think they would be used is to reduce the dyskinesia (the unwanted tremors) associated with L-DOPA?

Because as melonbar said above if you followed that pathway, I think the only answer would have been inhibition of movement.

[kensan]

I said inhibition too, but apparently it was more movement 

[ChickenCh0wM1en]

I said inhibition too, but apparently it was more movement 

Don't even know what to think anymore.

Slide 11 in Lecture 12 (Neurophys) says that D2R inhibits unwanted movement.
Online it says both so fuarkk.. so confusing..

[MelonBar]

Wat... how does indirect pathway inhibit movement then?

[ferrsal]

I found this on the internet

"Dopamine therefore increases the excitatory effect of the direct pathway (via D1 causing movement) and reduces the inhibitory effect of the indirect pathway (via D2 preventing full inhibition of movement)."

This makes sense in terms of D2 being inhibitory but at the same time being pro-movement. However, they never mentioned anything like this in the lecture even though it clarifies a lot of things. (?)

So in the case of that question, stimulating D2 receptors will lead to a greater inhibition of the indirect pathway and therefore ultimately increasing movement.

[emiinaaa]

I found this on the internet

"Dopamine therefore increases the excitatory effect of the direct pathway (via D1 causing movement) and reduces the inhibitory effect of the indirect pathway (via D2 preventing full inhibition of movement)."

This is what I had from my notes, he had said it in the lecture. So in that MST question, I think the answer was more movement

[ferrsal]

ah I must have missed that. that makes sense then!

[MelonBar]

D2 being inhibitory but at the same time being pro-movement.

[Whynot123]

How's NEUR30003 been treating you guys so far ?
Any advice/tips/recommendations etc...

Curious to know as I plan on taking the subject next year.

[nino quincampoix]

How's NEUR30003 been treating you guys so far ?
Any advice/tips/recommendations etc...

Curious to know as I plan on taking the subject next year.

I think that neuroscience is a subject that will appeal to some people but not others. As the title suggests, it covers the principles, so expect to cover a range of topics in varying levels of detail, some of which you may love, and others that won’t enjoy as much. As far as tips go, just work hard like you would in any other subject.