Hey guys
Could i get an explanation on why sex-linked genes don't produce simple mendelian ratios
For organisms under the XY sex determination system (e.g. humans or
Drosophila melanogaster [fruit/ vinegar fly]), females have two X chromosomes (XX), whereas males only have one and fill the other with a Y chromosome (XY) when they inherit sex chromosomes. This means that the presence of the Y chromosome makes an organism male under this system. Each of these sex chromosomes has alleles - these are known as sex-linked alleles (sometimes referred to as X-linked alleles). This is usually denoted as a superscript letter beside a capital X or Y as appropriate, such as X
wX
w for a white eyed female, where 'w' is the white eye allele.
Why it doesn't produce normal Mendellian ratios is because the progeny's sex will impact how much of the genetic info will be shown (but this isn't the end of the story, more on that below).
What do I mean by this? For sex-linked traits with the XY system, male progeny are
hemizygous (This basically means it only shows up one copy from its parents.); they'll display whatever trait their mother gave them (they need an X chromosome to live) and automatically receive the Y chromosome their father had (because where else can they get a Y chromosome to become male?). The Y chromosome is often considered 'too small to have visible effect' ("gene-poor") and thus, Dad's genes don't show up in the male progeny's phenotype.
Mendellian ratios would show that both sexes of the progeny will be the same (female + males show Mum + Dad's info). Under sex-linked ratios, females will show both Mum + Dad's info (since they have 2 X chromosomes and inherit these equally from the parents), but males will only show Mum's (hemizygous).
This difference causes the observed ratio differences.The best example I can give you is on this link
right here, which includes the research of Thomas Hunt Morgan on
Drosophila melanogaster (the experiment that essentially discovered the existence of sex-linked alleles).
Some more helpful links:
Sex-linked inheritanceSee halfway down the page under "Inheritance of Sex Linked Traits"NOTE: I got beaten by Potatohater, but I thought the links might be useful, so I'm posting anyway. Also, I know I explained it in a convoluted manner, but I hope it made sense. Since genetics is my major, I tend to have a more technical background.