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May 07, 2026, 10:12:01 am

Author Topic: Cell mediated immunity  (Read 1724 times)  Share 

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suskieanna

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Cell mediated immunity
« on: November 01, 2018, 07:38:44 pm »
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Hello guys I have these for the cell mediated immunity
- Infected or cancer cells present the relevant antigens on their MHCI markers.
- Cytotoxic T cell (Tc cells) binds to the antigen, and with the help of cytokines produced by helper T cells, they proliferate and differentiate into active Tc cells and memory Tc cells.
- The active Tc cells then recognise their specific infected cells and cancerous cells, and secret a chemical called perforin, which punctures the cell membrane of the infected or cancerous cell that destroys them. Alternatively, they use their Fas signalling molecule (on their cell surface) to bind to death receptors on the target cell that initiates apoptosis. 

Do you think I included all the relevant informations? Thanks!

C14M8S

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Re: Cell mediated immunity
« Reply #1 on: November 01, 2018, 07:46:21 pm »
+2
That's about right. Don't overcomplicate it.
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Erutepa

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Re: Cell mediated immunity
« Reply #2 on: November 01, 2018, 08:01:46 pm »
+1
Hello guys I have these for the cell mediated immunity
- Infected or cancer cells present the relevant antigens on their MHCI markers.
- Cytotoxic T cell (Tc cells) binds to the antigen, and with the help of cytokines produced by helper T cells, they proliferate and differentiate into active Tc cells and memory Tc cells.
- The active Tc cells then recognise their specific infected cells and cancerous cells, and secrete a chemical called perforin, which punctures the cell membrane of the infected or cancerous cell that destroys them. Alternatively, they use their Fas signaling molecule (on their cell surface) to bind to death receptors on the target cell that initiates apoptosis. 

Do you think I included all the relevant information? Thanks!
This information is good.
Just remember that cells don't specifically present viral/cancerous proteins on their MHC class I. They will present many different proteins produced in the cell, just that the cytotoxic T cells will only react to the proteins indicative of viruses or cancer.
In avoiding detection by cytotoxic T cells, viruses and cancer may sometimes downregulate MHC class I proteins, but that is then where NK cells come in.
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vox nihili

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Re: Cell mediated immunity
« Reply #3 on: November 01, 2018, 09:42:14 pm »
+2
This information is good.
Just remember that cells don't specifically present viral/cancerous proteins on their MHC class I. They will present many different proteins produced in the cell, just that the cytotoxic T cells will only react to the proteins indicative of viruses or cancer.
In avoiding detection by cytotoxic T cells, viruses and cancer may sometimes downregulate MHC class I proteins, but that is then where NK cells come in.

Whilst this is all right, I don't think this is necessarily helpful information for the VCE course. The OP has given a really good explanation of cell-mediated immunity for VCE here :)
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