I remember posting 4 as a challenge once lol
Suppose the sum of the first n terms is an integer m, multiply both sides by n!:
!)
Now consider the biggest prime number p, in the sequence 1,2,3...n.
m*n! is divisible by p. All the terms on the RHS are divisible by p except for the pth term. This is because the kth term is a product of all numbers between 1 and n except for k. Therefore if

the kth term is divisible by p. If

then the kth term is missing p. But no other factor of this term is divisible by p since they are made of prime factors smaller than p. Denote the kth term as

:

So the LHS is not divisible by p, but the RHS is since it is a linear combination of multiples of p, a contradiction.
edit: actually, I think there is a flaw with this proof since it assumes that for every integer n, there exists a prime p such that p<n<2p, and i do not know if this is true.
However an alternate proof is this: multiply both sides by the biggest power of 2(call this

), then multiply it by the biggest power of 3, then multiply it by the biggest power of 5 etc. eventually we get some equation like in the previous attempt at a proof, that is one that involves only integers. Now the

term is not an even number, but the rest must be and so we get a contradiction since we get:
even numer=sum of even numbers + odd number.
1.)
)
,
(n^2+1)-1)
any prime that divides the numerator must divide either
n or

.
Suppose p divides n. Then:

hence p does not divide the denominator.
Suppose p divides

:
(n^2+1)}{p} - \frac{1}{p} \notin \mathbb{N})
hence p does not divide the numerator.
Therefore no prime can divide both the numerator and denominator. Hence they are relatively prime and so in lowest terms.
3.) suppose some integer

, divides

and

then

hence

. Now

hence

. Now

hence

... etc and we can imagine continuing this process until we get to

and

which is false since no integer greater than 1 divides both of these(2 and 3).