Mmm yeh, I see the problem here that Russ has brought up =/ Never thought of it like that but it's a fair point. For example, glucocorticoids (a type of steroid) pretty much bind to an intracellular receptor, and this complex then moves into the nucleus and binds to promoter regions on target genes. Other steroids operate in a similar manner. Given that there isn't really an amplification of the signal, I would be hesitant to call this transduction as well. I think it really depends on what definition you use. Some sources seem to use it just to state any sort of extracellular message changing something intracellularly. I've seen other definitions which mention it must specifically bind to extracellular receptors. However, the VCE definition seems to always require mentioning some sort of amplification of the signal if I remember correctly, so I'd stick with this one. Either way, doubt it's going to be tested. Just know your definition of signal transduction word for word (probably comes up every second VCAA exam) and you'll be fine.