The P=I2R, I is not constant because P=VI, I must change to balance the power, R is constant and is the resistance of the transmission lines. With V=IR, if I is constant and we change the resistance to get the voltage drop, i.e. replace a load with a greater resistance and the voltage drop increases. If R is constant, then increasing the voltage decreases increases the current. It all depends on what is staying constant in the equations. I hope that makes sense, because I think I've confused myself now???
When it is being stepped up, the resistance of the wire has nothing to do with it as the power has to stay the same, hence P1=P2, V1I1=V2I2
With the power loss, we cannot use the voltage drop in the wire unless it is stated, so we must use I and R, so Ploss=I2R